Key result
Advancing age from 2 to 12 years in beagles increased cerebral artery contractions mediated by histamine H1 and serotonin receptors, while responses to vasodilators did not significantly differ.
Why the study?
Does advancing age alter the responsiveness of beagle cerebral arteries to vasoconstrictor and dilator agents?
Does advancing age alter the responsiveness of beagle cerebral arteries to vasoconstrictor and dilator agents?
Aging in beagles selectively increases cerebral artery contractile responses to histamine and serotonin without altering responses to other tested constrictors or dilators.
Aging may heighten cerebral vasoconstriction in beagles; leaves open translation to human cerebrovascular risk or therapy.
With advancing age from 2 to 12 years, contractions of isolated beagle cerebral arteries mediated by histamine H1 and serotonin receptors increased, whereas those induced by noradrenaline and angiotensin II did not differ. Relaxations by vasodilator substances, such as prostaglandin (PG) I2, isoproterenol, adenosine and K+ (5 mM), and by stimulation of vasodilator nerves in the adult and senescent beagle arteries did not significantly differ.
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Shimizu et al. (1986) studied Senescence. Advancing age (senescence) vs. Adult (younger) beagle arteries was evaluated on Contractions mediated by histamine H1 and serotonin receptors, and relaxations by vasodilator substances. Advancing age from 2 to 12 years in beagles increased cerebral artery contractions mediated by histamine H1 and serotonin receptors, while responses to vasodilators did not significantly differ.
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