Screwed in place: An anti-parallel double-helical aromatic oligoamide foldamer was shown to bind to a series of rodlike guests of various lengths upon the winding of the duplex around the guests (see scheme). Solid-state crystal structures of the host–guest complexes show that the two strands of the duplex undergo a relative screw motion to adjust the distance between hydrogen-bond donors located at the end of one of their extremities so that they bind to hydrogen-bond acceptors of the guest.
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Ferrand et al. (2011) studied this question.
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