Key result
Intermittent urine oxygen tension ≥ 130.1 mmHg at six hours after ICU admission was associated with a lower risk of acute kidney injury (OR 0.19), although predictive accuracy was low (AUC 0.68).
Why the study?
Although novel biomarkers of acute kidney injury are being developed, none are universally available.
Does intermittent urine oxygen tension monitoring predict acute kidney injury in patients undergoing elective cardiovascular surgery requiring cardiopulmonary bypass?
Observational (n=50)
No
Does intermittent urine oxygen tension monitoring predict acute kidney injury in patients undergoing elective cardiovascular surgery requiring cardiopulmonary bypass?
Intermittent urine oxygen tension monitoring using a standard blood gas analyzer showed limited predictive value for acute kidney injury after cardiovascular surgery, with low AUCs.
Intermittent PuO2 monitoring shows limited AKI prediction after cardiac surgery; hypothesis-generating and should not yet change practice.
Novel biomarkers of acute kidney injury (AKI) are being developed and commercialized. However, none are universally available. The aim of this preliminary prospective observational study was to explore the effectiveness of intermittent urine oxygen tension (PuO2) monitoring without special equipment (using a blood gas analyzer) for predicting AKI after elective cardiovascular surgery requiring cardiopulmonary bypass (CPB).
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Kato et al. (2021) conducted an observational in Acute Kidney Injury (n=50). Intermittent urine oxygen tension (PuO2) ≥ 130.1 mmHg vs. PuO2 < 130.1 mmHg was evaluated on Prediction of acute kidney injury at 6 hours after ICU admission (T3) (OR 0.19, 95% CI 0.05-0.75, p=0.018). Intermittent urine oxygen tension ≥ 130.1 mmHg at six hours after ICU admission was associated with a lower risk of acute kidney injury (OR 0.19), although predictive accuracy was low (AUC 0.68).
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