Key result
Cardioprotective agents such as beta-blockers and ACE inhibitors, along with liposomal anthracyclines, are highlighted as key strategies to prevent and treat chemotherapy-induced cardiotoxicity.
Why the study?
There are conflicting data on ways to overcome cardiotoxicity induced by commonly used anticancer drugs.
Beta-blockers and ACE inhibitors are commonly used to prevent chemotherapy-induced cardiotoxicity, but their blood pressure-lowering effects require careful management in normotensive cancer patients.
This review presents modern strategies for the prevention and treatment of cardiotoxicity induced by the most commonly used anticancer drugs such as anthracycline antibiotics, monoclonal antibodies, tyrosine kinase inhibitors. There are a large number of conflicting data on ways to overcome the cardiotoxicity of anticancer drugs. The creation of a complex of diagnostic measures will allow to identify the earliest signs of heart damage during chemotherapy and to develop timely preventive measures to prevent cardiotoxicity, improve the quality of life and prognosis of patients. Currently, a large number of small publications on the prevalence, prediction and prevention of cardiotoxicity in cancer patients, including the primary and secondary prevention of cardiotoxicity, are available. Beta-blockers and inhibitors of angiotensin-converting enzyme most often use as cardioprotective agents. There is evidence of poor tolerability of treatment with these drugs for young patients. Most drugs reduce blood pressure, which can adversely affect the health of patients without associated hypertension. Coordinated work between cardiologists and oncologists is needed to create common terminology, to define cardiovascular events and create registers, meta-analyzes, generally accepted recommendations, guidelines for the management of patients at risk of developing cardiotoxicity. This review used published articles the Scopus, Pubmed database, articles from The New England Journal of Medicine, Annals of Oncology, and periodicals of the Russian Federation over the past 10 years, as well as publications from previous years.
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Ибрагимова et al. (2018) conducted a review in Chemotherapy-induced cardiotoxicity. Cardioprotective agents (beta-blockers, ACE inhibitors, liposomal anthracyclines) was evaluated. Cardioprotective agents such as beta-blockers and ACE inhibitors, along with liposomal anthracyclines, are highlighted as key strategies to prevent and treat chemotherapy-induced cardiotoxicity.
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