Cytokines as soluble proteins or growth factors involved in cellular interactions are major contributors to allergic and immune-mediated inflammation. Chemokines are chemoattractive cytokines subdivided into families based on cysteine residues. This review on corticosteroid effects on cytokines and chemokines will consider only a selected number of several of these proteins studied in our division and in other centers. Characteristics of several major cytokines up to IL-15, chemokine targets and the effect of corticosteroids on various cells, cytokines, and chemokines are reviewed. The effect of corticosteroid inhibitors of non-specific endothelial activation, selective activation of VCAM-1 expression, eosinophil priming and chemokine production related to allergic diseases is illustrated. The effect of nasal corticosteroids on IL-1 beta, RANTES, IL-6, and IL-8 is also discussed.
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Marianne Frieri (1999) studied this question.
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