A benign prostate gland containing corpora amylacea within its lumen was observed within a prostatic nerve in the subcapsular region of a radical prostatectomy specimen. It was cytohistologically distinct from the focal high-grade periurethral prostate cancer, from which it was separated by a distance of 2 cm. Perineural invasion represents an intimate neural-epithelial interaction, and evidence is presented to support the notion that nerves may play an active role in the development of such relationships. Nerve growth factors produced by neoplastic tissue may mediate this phenomenon.
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Stewart F. Cramer (1981) studied this question.