Several biological changes occur when streptozocin is given to experimental animals. The rat streptozocin (STZ) model is extensively used in diabetic experiments. In this brief report, the main physiological characteristics of rats injected with streptozocin are presented. These characteristics are manifested by weight loss, organ weight reduction, serum glucose elevation, decrease in serum insulin level, and other enzyme and hormonal changes. A collection of these parameters may be helpful in establishing a database to describe this model.
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Al-Achi et al. (2001) studied this question.
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