Key result
Warfarin disposition is highly variable and influenced by factors including gender, age, genetic variation, body surface area, concurrent drugs, weight, and ethnicity.
Why the study?
Warfarin pharmacokinetics in its enantiomeric form have been reported to be highly variable.
Systematic Review (n=5)
Multiple demographic, clinical, and genetic factors influence warfarin pharmacokinetics, supporting the potential utility of model-informed dosing in clinical practice.
Supports model-informed warfarin dosing; extends one-compartment PK models with quantified covariates.
Warfarin is the most commonly prescribed anti-coagulant medication. Warfarin’s pharmacokinetics (PK) in its enantiomeric form have been reported to be highly variable. Five population pharmacokinetic model studies for warfarin were identified in this systematic review. This review summarized these studies and reported on various factors affecting warfarin PK. Most studies reported a one-compartment model with first-order absorption and elimination for both S-warfarin and R-warfarin. Warfarin disposition has been reported to be influenced by various factors, including gender, age, genetic variation, body surface area (BSA), concurrent drug, weight, and ethnicity. So, all of these factors must be considered when addressing this pharmacokinetic variability. These models should undergo an external evaluation to confirm their generalizability and to support model-informed dosing in clinical settings.
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Mahaboob et al. (2023) conducted a systematic review in Warfarin pharmacokinetics (n=5). Warfarin was evaluated on Factors affecting warfarin pharmacokinetics. Warfarin disposition is highly variable and influenced by factors including gender, age, genetic variation, body surface area, concurrent drugs, weight, and ethnicity.
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