Key result
Carriers of the rare allele of the LRRFIP1 rs11680012 polymorphism had 30% more abdominal adiposity and 75% higher CRP levels than common allele carriers.
Why the study?
Do polymorphisms in the LRRFIP1 gene associate with adiposity and markers of inflammation in participants of the Quebec Family Study?
Observational (n=926)
Do polymorphisms in the LRRFIP1 gene associate with adiposity and markers of inflammation in participants of the Quebec Family Study?
p-value: p=1.6 x 10^-4
A variant in the LRRFIP1 gene (rs11680012) is significantly associated with increased abdominal adiposity and systemic inflammation, highlighting a potential genetic link to cardiometabolic risk.
LRRFIP1 rs11680012 variant was associated with adiposity and inflammation; hypothesis-generating for cardiometabolic genetics and needs replication before any clinical use.
Inflammation is an important factor linking abdominal obesity with insulin resistance and related risk. A genome-wide association study of adiposity-related traits performed in the Family Study (QFS) revealed that a single-nucleotide polymorphism (SNP) in the LRRFIP1 gene (rs11680012) was associated with abdominal adiposity (P ¼ 4.6 10–6 ). : The objective of this study was to assess the relationship between polymorphisms in 1 gene and adiposity (BMI, fat mass (FM), waist circumference (WC), and computed tomographyderived areas of total, subcutaneous and visceral abdominal adipose tissue) and markers of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)). and Methods: Using Sequenom, 16 tag SNPs in the LRRFIP1 gene, capturing 78% of the variation, were genotyped in 926 participants of the QFS. : Eight SNPs (rs7575941, rs3769053, rs11689421, rs3820808, rs11680012, rs3806505, 6739130, and rs11686141) showed evidence of association with at least two adiposity phenotypes and levels of one marker of inflammation. The strongest evidence of association was observed with 11680012, which explained 1.8–3.4% of the variance in areas of abdominal adiposity and 2.0% of the in CRP levels. Carriers of the rare allele of rs11680012 had 30% more abdominal adiposity (P between 2.7 10–4 and 3.8 10–6 ) and 75% higher CRP levels (P ¼ 1.6 10–4 ) than the allele in age and sex adjusted data. Rs11680012 is a G/C SNP converting an arginine into a and this amino acid substitution may potentially alter exonic splicing. : This gene may therefore represent a potential interesting target to investigate in further studies on adiposity and inflammation.
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Plourde et al. (2012) conducted an observational in Adiposity and inflammation (n=926). Rare allele of the LRRFIP1 rs11680012 polymorphism vs. Common allele of rs11680012 was evaluated on Abdominal adiposity and C-reactive protein (CRP) levels (p=1.6 x 10^-4). Carriers of the rare allele of the LRRFIP1 rs11680012 polymorphism had 30% more abdominal adiposity and 75% higher CRP levels than common allele carriers.
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