Key result
A living-donor liver transplant successfully rescued a 23-year-old male with severe HAV-induced acute liver failure who had failed supportive medical treatment.
Why the study?
Although HAV infection is prevalent, HAV-induced ALF is very rare, typically more common in older patients, and has a worse prognosis.
Does living-donor liver transplant improve survival in a patient with HAV-induced acute liver failure unresponsive to supportive care?
Case Report (n=1)
No
Does living-donor liver transplant improve survival in a patient with HAV-induced acute liver failure unresponsive to supportive care?
Living-donor liver transplant can successfully rescue highly-selected patients with severe HAV-associated acute liver failure who fail supportive medical therapy.
Answers are grounded in this paper and cite their sources.
Living-donor liver transplant may rescue selected HAV acute liver failure cases; hypothesis-generating and leaves open survival benefit.
Though HAV infection is prevalent in the general population, HAV-induced ALF is very rare.ALF due to HAV are more common in elder patients’ group, and it has a worse prognosis. A 23-year-old south Indian male presented with fever, jaundice, and malaise, who had positive anti HAV IgM antibodies, developed hepatic encephalopathy which ultimately led to a diagnosis of acute liver failure due to acute hepatitis A virus infection. Despite the failure of supportive treatment, he was managed successfully with a living donor liver transplant.
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Redekar et al. (2020) conducted a case report in HAV induced acute liver failure (n=1). Living-donor liver transplant vs. Supportive treatment (prior) was evaluated on Patient survival and recovery of liver function. A living-donor liver transplant successfully rescued a 23-year-old male with severe HAV-induced acute liver failure who had failed supportive medical treatment.
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