Sera of patients with ankylosing spondylitis (AS) were screened for the presence of antibodies by indirect immunofluorescence staining of polytene chromosomes of Drosophila melanogaster. Thirty-nine percent of the sera tested contained antibodies which selectively reacted with an antigen(s) present at the chromosomal locus 93D after heat shock treatment. This indicates a novel antibody specificity in a subgroup of AS patients and may provide a new aid in the diagnosis of AS.
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Lakomek et al. (1984) studied this question.
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