Key result
Castrol GTX3 provided an in vitro testing environment with lubricity similar to that of a living organism, whereas physiological saline was well below that of human soft tissues and tissue fluids.
Why the study?
Current ASTM standards require only testing in physiological saline to simulate in vivo conditions during standard testing of spinal implants.
Castrol GTX3 motor oil provides a more biologically accurate lubricating environment for in vitro mechanical testing of spinal implants compared to standard physiological saline.
Saline-based in vitro spinal implant testing may underestimate lubricity; leaves open whether Castrol GTX3 improves predictive accuracy for clinical performance.
BACKGROUND: The American Society for Testing and Materials (ASTM), considered the gold standard worldwide, requires only testing in physiological saline solution to simulate in vivo conditions in standard testing of spinal implants. RESEARCH DESIGN AND METHODS: We conducted an in vitro study to identify an industrial lubricant with characteristics that are most similar to those of biologically lubricating fat, blood, and tissue fluids. The use of such a material could standardize the results of in vitro mechanical tests for better clinical applications. RESULTS: Our study has shown that the lubricity of physiological saline was well below that of human soft tissues and tissue fluids, and among the motor oils, Castrol GTX3 provided a testing environment similar to that of a living organism. CONCLUSIONS: With the intention of standardizing and preventing a biological hazard, we have developed a reproducible mechanical testing proposal based on our experiments, which, in addition, would allow us to avoid many misunderstandings and contingencies.
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Csernátony et al. (2022) studied Spinal implants testing. Castrol GTX3 vs. Physiological saline solution was evaluated on Lubricity compared to human soft tissues and tissue fluids. Castrol GTX3 provided an in vitro testing environment with lubricity similar to that of a living organism, whereas physiological saline was well below that of human soft tissues and tissue fluids.
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