Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2001Cardiovascular ResearchOpen Access

The angiopoietin–tie2 system in coronary artery endothelium prevents oxidized low-density lipoprotein-induced apoptosis

View Full Paper
Ask AI
Bookmark
Share

Key result

Angiopoietin-1 (200 ng/ml) induced Tie2 phosphorylation and dose-dependently increased the survival of cultured porcine coronary artery endothelial cells during OxLDL-induced apoptosis.

Population

Cultured porcine coronary artery endothelial cells (PCAECs) and explanted porcine coronary arteries

Comparison

Angiopoietin-1 and Angiopoietin-2 vs Control (no Ang1/Ang2) or OxLDL alone

Design

Preclinical

Authors

IKInjune KimCreative Research

Discussion

Loading...

Member takes

Overview

Suggests Ang1-Tie2 as endothelial protector in atherosclerosis models; leaves open in vivo and clinical translation.

Structured PICO

P
Population
Cultured porcine coronary artery endothelial cells (PCAECs) and explanted porcine coronary arteries
I
Intervention
Angiopoietin-1 (Ang1) (200 ng/ml) and Angiopoietin-2 (Ang2) (200 ng/ml)
C
Comparator
Control (no Ang1/Ang2) or OxLDL alone
O
Outcome
Tie2 phosphorylation and endothelial cell survival during oxidized low-density lipoprotein (OxLDL)-induced apoptosissurrogate

The Ang1-Tie2 system enhances endothelial cell survival against OxLDL-induced apoptosis, suggesting a protective role in maintaining coronary artery endothelial integrity.

Cite This Study

Injune Kim (2001) studied OxLDL-induced apoptosis in coronary artery endothelium. Angiopoietin-1 (Ang1) vs. Angiopoietin-2 (Ang2) or control was evaluated on Tie2 phosphorylation and endothelial cell survival during OxLDL-induced apoptosis. Angiopoietin-1 (200 ng/ml) induced Tie2 phosphorylation and dose-dependently increased the survival of cultured porcine coronary artery endothelial cells during OxLDL-induced apoptosis.

synapsesocial.com/papers/6a92fc5d3fd07a407cc6af5ehttps://doi.org/10.1016/s0008-6363(00)00295-9
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway2000 · 653 citations
  2. 2Angiopoietin-1 Inhibits Endothelial Cell Apoptosis via the Akt/Survivin Pathway2000 · 639 citations
  3. 3Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells1999 · 495 citations
  4. 4Angiopoietin‐1 is an apoptosis survival factor for endothelial cells1999 · 240 citations
  5. 5Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues1997 · 418 citations