Case Studies1 June 1964Familial Pheochromocytoma and Thyroid CarcinomaDAVID S. NOUROK, M.D.DAVID S. NOUROK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-6-1028 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPheochromocytoma is a catecholamine-secreting tumor arising either from the adrenal medulla or from chromaffin tissue located elsewhere in the body. A familial occurrence has been demonstrated, with sixteen affected kindred thus far reported (1-15). An association with thyroid carcinoma has also been shown (12, 16, 17) and two recent publications (14, 18) have reported the thyroid carcinoma to be a newly described (19) medullary (solid) carcinoma with amyloid infiltration.This report will describe the occurrence of bilateral pheochromocytoma and of thyroid carcinoma in a mother and her daughter. The mother died after attempted adrenalectomy 25 years ago. The daughter recently...References1. HYMANMENCHER AWH: Pheochromocytoma of the adrenal gland. J. Urol. 49: 755, 1943. CrossrefGoogle Scholar2. CALKINSHOWARD EJE: Bilateral familial phaeochromocytomata with paroxysmal hypertension: successful surgical removal of tumors in two cases, with discussion of certain diagnostic procedures and physiological considerations. J. Clin. Endocr. 7: 475, 1947. CrossrefGoogle Scholar3. LOHMANN V: Über diabetes mellitus bei nebennierenmarktumoren. Deutsch. Med. Wschr. 75: 138, 1950. CrossrefGoogle Scholar4. ROTHHIGHTOWERBARKERPRIESTLEY GMNCNWJT: Familial pheochromocytoma: report on three siblings with bilateral tumors. Arch. Surg. (Chicago) 67: 100, 1953. CrossrefGoogle Scholar5. YOUNGMURRAY RCWA: Familial adrenal phaeochromocytoma with sustained hypertension. Canad. Med. Ass. J. 72: 503, 1955. MedlineGoogle Scholar6. KELSALLROSS AREJ: Bilateral phaeochromocytoma in two sisters. Lancet 2: 273, 1955. CrossrefGoogle Scholar7. CONEALLENPEARSON TEMSHA: Pheochromocytoma in children: report of three familial cases in two unrelated families. Pediatrics 19: 44, 1957. MedlineGoogle Scholar8. GREENBERGGARDNER RELI: Pheochromocytoma in father and son: report of eighth known affected kindred. J. Clin. Endocr. 19: 351, 1959. CrossrefGoogle Scholar9. COOKURICHSAMPLEFAWCETT JERWHGNW: Peculiar familial and malignant pheochromocytomas of organs of Zuckerkandl. Ann. Intern. Med. 52: 126, 1960. LinkGoogle Scholar10. CARMANBRASHEAR CTRE: Pheochromocytoma as an inherited abnormality: report of the tenth affected kindred and review of the literature. New Eng. J. Med. 263: 419, 1960. CrossrefGoogle Scholar11. HRADECMARATKAPALECKOVA EZM: Le phéochromocytome à caractère familial. J. Chir. (Paris) 81: 479, 1961. MedlineGoogle Scholar12. SMITSHUIZENGA MJ: Familial occurrence of phaeochromocytoma. Acta Genet. (Basel) 11: 137, 1961. Google Scholar13. GRUNSTEINFINKELSTEIN IWE: Pregnancy complicated by bilateral pheochromocytoma with fatal outcome: simultaneous occurrence in siblings. Amer. J. Obstet. Gynec. 83: 508, 1962. CrossrefMedlineGoogle Scholar14. CUSHMAN P: Familial endocrine tumors: report of two unrelated kindred affected with pheochromocytomas, one also with multiple thyroid carcinomas. Amer. J. Med. 32: 352, 1962. CrossrefMedlineGoogle Scholar15. TISHERMANGREGGDANOWSKI SEFJTS: Familial pheochromocytoma. JAMA 182: 152, 1962. CrossrefMedlineGoogle Scholar16. SIPPLE JH: Association of pheochromocytoma with carcinoma of the thyroid gland. Amer. J. Med. 31: 163, 1961. CrossrefGoogle Scholar17. SAHAY U: Bilateral phaeochromocytoma associated with carcinoma of the thyroid. Brit. Med. J. 5289: 1391, 1962. CrossrefGoogle Scholar18. MANNINGMOLNARBLACKPRIESTLEYWOOLNER PCGDBMJTLB: Pheochromocytoma, hyperparathyroidism and thyroid carcinoma occurring coincidentally: report of a case. New Eng. J. Med. 268: 68, 1963. CrossrefGoogle Scholar19. HAZARDHAWKCRILE JBWAG: Medullary (solid) carcinoma of the thyroid: a clinicopathologic entity. J. Clin. Endocr. 19: 152, 1959. CrossrefMedlineGoogle Scholar20. JACOBSSOBELHENRY SLCRJ: Specificity of the trihydroxyindole method for determination of urinary catecholamines. J. Clin. Endocr. 21: 305, 1961. CrossrefMedlineGoogle Scholar21. BRUNJESWYBENGA SD: Differential fluorimetry in catecholamine determination: a simplified method of calculation. Clin. Chem. 9: 626, 1963. CrossrefGoogle Scholar22. BRUNJESWYBENGAJOHNS SDVJ: Fluorimetric determination of urinary metanephrine and normetanephrine. Clin. Chem. 10: 1, 1964. CrossrefMedlineGoogle Scholar23. BRUNJESWYBENGASPROEDCHANEY SDJA: A vanillylmandelic acid procedure using an ion exchange resin for the initial separation. Clin. Chem. 8: 452, 1962. Google Scholar24. SOFFERDORFMANGABRILOVE LJRIJL: The Human Adrenal Gland, Lea & Febiger, Philadelphia, 1961, p. 552, 553. Google Scholar25. SHERWIN RP: Histopathology of pheochromocytoma. Cancer 12: 86, 1959. CrossrefGoogle Scholar26. GLUSHIENMANSUYLITTMAN ASMMDS: Pheochromocytoma: its relationship to neurocutaneous syndromes. Amer. J. Med. 14: 318, 1953. CrossrefMedlineGoogle Scholar27. CHAPMANKAMPTALIAFERRO RCVEI: Pheochromocytoma associated with multiple neurofibromatosis and intracranial hemangioma. Amer. J. Med. 26: 883, 1959. CrossrefMedlineGoogle Scholar28. HAYLESKENNEDYBEAHRSWOOLNER ABRLOHLB: Management of the child with thyroidal carcinoma. JAMA 173: 21, 1960. CrossrefMedlineGoogle Scholar29. MEIERWOOLNERBEAHRSMCCONAHEY DWLBOHWM: Parenchymal findings in thyroidal carcinoma: pathologic study of 256 cases. J. Clin. Endocr. 19: 162, 1959. CrossrefGoogle Scholar30. DEGROOTHALLMCDERMOTTDAVIS LJRWVAM: Hashimoto's thyroiditis: a genetically conditioned disease. New Eng. J. Med. 267: 267, 1962. CrossrefMedlineGoogle Scholar31. SCHLIKEHILLSCHULTZ CPJEGR: Carcinoma in chronic thyroiditis. Surg., Gynec. Obstet. 111: 552, 1960. MedlineGoogle Scholar32. DAILYLINDSEYSKELERN MESR: The relation of thyroid neoplasms to Hashimoto's disease of the thyroid gland. Arch. Surg. (Chicago) 70: 291, 1955. CrossrefGoogle Scholar33. SHIBATAOGAWAITAGAKI KES: Effect of autonomic drugs on radioactive iodine uptake by thyroid gland. Endocr. Jap. 1: 69, 1954. CrossrefMedlineGoogle Scholar34. HAYSSOLOMON MTDH: Effect of epinephrine on radioactive iodine uptake in thyroids of normal subjects. Clin. Research 9: 72, 1961. Google Scholar35. FUTTERWEITALLANMOSER WLM: Pheochromocytoma with radioactive iodine uptake and electrocardiographic abnormalities: case report with a review of thyroid-adrenal medullary interrelationships. Metabolism 11: 589, 1962. Google Scholar36. MIEHERHARTSOCKGEOKASBALLARDFRAME WCRJMCHSB: Peptic ulcer as a manifestation of familial polyendocrine disease. JAMA 179: 854, 1962. CrossrefMedlineGoogle Scholar37. WERMER P: Endocrine adenomatosis and peptic ulcer in a large kindred: inherited multiple tumors and mosaic pleiotropism in man. Amer. J. Med. 35: 205, 1963. CrossrefMedlineGoogle Scholar38. ROTHKVALE GWF: Histamine test: a tentative test for pheochromocytoma. Amer. J. Med. Sci. 210: 653, 1945. CrossrefGoogle Scholar39. ROTHKVALE BWF: Evaluation of pharmacologic tests as an aid in the diagnosis of pheochromocytoma. Dis. Chest. 32: 295, 1957. CrossrefMedlineGoogle Scholar40. KVALEROTHMANGERPRIESTLEY WFGMWMJR: Present day diagnosis and treatment of pheochromocytoma. JAMA 164: 854, 1957. CrossrefMedlineGoogle Scholar41. TAYLORSTOELTING CVK: Acute hypertension during anesthesia: the unsuspected pheochromocytoma. JAMA 173: 753, 1960. CrossrefMedlineGoogle Scholar42. MINNOBENNETTKVALE AMWAWF: Pheochromocytoma: a study of 15 cases diagnosed at autopsy. New Eng. J. Med. 251: 959, 1954. CrossrefMedlineGoogle Scholar43. SAYERMOSERMATTINGLY WJMTW: Pheochromocytoma and the abnormal electrocardiogram. Amer. Heart. J. 48: 42, 1954. CrossrefMedlineGoogle Scholar44. JOHNSBRUNJES VJS: Pheochromocytoma. Amer. J. Cardiol. 9: 120, 1962. CrossrefMedlineGoogle Scholar45. GOLDENBERG M: Adrenal medullary function. Amer. J. Med. 10: 627, 1951. CrossrefMedlineGoogle Scholar46. GOLDENBERGSARLINEDWARDSRAPPAPORT MITMM: Clinical screening methods for diagnosis of pheochromocytoma. Amer. J. Med. 16: 310, 1954. CrossrefMedlineGoogle Scholar47. MANGERFLOCKBERKSONBOLLMANROTHBALDESJACOBS WMEVJJLGJEJM: Chemical quantitation of epinephrine and norepinephrine in thirteen patients with pheochromocytoma. Circulation 10: 641, 1954. CrossrefMedlineGoogle Scholar48. VON EULERSTROM USG: Present status of diagnosis and treatment of pheochromocytoma. Circulation 15: 5, 1957. CrossrefMedlineGoogle Scholar49. GITLOWMENDLOWITZKHASSISCOHENSHA SEESGJ: The diagnosis of pheochromocytoma by determination of urinary 3-methoxy, 4-hydroxymandelic acid. J. Clin. Invest. 39: 221, 1960. CrossrefMedlineGoogle Scholar50. JACOBSSOBELHENRY SLCRJ: Excretion of 3-methoxy, 4-hydroxymandelic acid and catecholamines in patients with pheochromocytoma. J. Clin. Endocr. 21: 315, 1961. CrossrefGoogle Scholar51. CROUTPISANOSJOERDSMA RJJJA: Urinary excretion of catecholamines and their metabolites in pheochromocytoma. Amer. Heart. J. 61: 375, 1961. CrossrefMedlineGoogle Scholar52. SHANKELBRUNJESJOHNS SSVT: New in vivo assay of monamine oxidose activity. Clin. Research 10: 90, 1962. Google Scholar53. GOODALLKIRSHNERROSEN MNL: Metabolism of noradrenaline in human. J. Clin. Invest. 38: 707, 1959. CrossrefMedlineGoogle Scholar54. LABROSSEAXELRODKETY EHJSS: O-methylation, the principal route of metabolism of epinephrine in man. Science 128: 593, 1958. CrossrefMedlineGoogle Scholar55. KIRSCHNERGOODALLROSEN NML: Effect of iproniazid on metabolism of L-epinephrine-2-C14 in human. J. Pharmacol. Exp. Ther. 127: 1, 1959. MedlineGoogle Scholar56. FINEGOLDHADDAD MJJR: Multiple endocrine tumors. Arch. Path. (Chicago) 76: 449, 1963. Google Scholar57. FIELDSBURKETT MLLL: Multiple endocrine and metabolic disease syndrome. JAMA 188: 321, 1964. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DAVID S. NOUROK, M.D.Affiliations: Los Angeles, CaliforniaFrom the Department of Medicine, University of California, Los Angeles, California.This work was supported by grant AM-5035 United States Public Health Service, Bethesda, Maryland, under which Dr. Nourok was a Fellow in Medicine.Requests for reprints should be addressed to David S. Nourok, M.D., 3333 E Street, San Bernardino, California 92405. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Manifestations of Multiple Endocrine Neoplasia Type 2Cerebellar hemangioblastoma and primary hyperparathyroidismGlomus Tumor and Multiple Endocrine NeoplasiaGlomus Tumor and Multiple Endocrine NeoplasiaMultiple endocrine neoplasia syndromesPluriglanduläre endokrine RegulationsstörungenMultiple Endocrine Neoplasia, Type II (MEN II)Operationen bei malignen SchilddrüsenerkrankungenFamilial pheochromocytoma: a rare case of hydronephrosis and hydroureter in two generationsBook reviewComputed Brain and Orbital Tomography. Technique and Interpretation. By GonzalezCarlos F., GrossmanCharles B., and PalaciosEnrique, pp. xii + 276, 200 figs. (Chichester, John Wiley), £21·76.Catecholamines and the Sympathoadrenal SystemMedullary carcinoma of the thyroidMultiple endocrine adenomatosis—I and IIPhaeochromocytomaMultiple Endocrine AdenomatosisTHE PARANEOPLASTIC SYNDROMES ASSOCIATED WITH CARCINOMA OF THE THYROID GLANDFamilial Pheochromocytoma: Case Report and Review of the LiteraturePhaeochromocytoma and Other Catecholamine-Producing TumoursEarly Diagnosis of Medullary Carcinoma of the Thyroid Gland by Means of Calcitonin AssayPheochromocytoma Associated with Parathyroid Adenoma. Report of a Case and Review of LiteratureFamilial PheochromocytomaFamilial medullary thyroid carcinoma, pheochromocytoma, and parathyroid adenoma (Sipple's syndrome)Study of a kindredFamiliär auftretendes Adrenalin produzierendes Phäochromocytom in Kombination mit medullärem Thyreoidea-CarcinomPHEOCHROMOCYTOMATwo cell types in familial medullary thyroid carcinomaPheochromocytoma and Hyporesponsiveness to Thyrotrophin in a 46 XY Male with Features of the Turner PhenotypeCHARLES E. BECKER, M.D., SAUL W. ROSEN, M.D., PH.D., KARL ENGELMAN, M.D.Biochemistry of Functional Neural Crest TumorsAssociation of thyroid carcinoma and chemodectomaMEDULLARY THYROID CARCINOMAS WITH BILATERAL PHAEOCHROMOCYTOMASMultiple mucosal neuromas, pheochromocytoma and medullary carcinoma of the thyroid—a syndromeSyndrome of Bilateral Pheochromocytoma, Medullary Thyroid Carcinoma and Multiple NeuromasFamilial Occurrence of Parathyroid Adenomas, Pheochromocytoma, and Medullary Carcinoma of the Thyroid with Amyloid Stroma (Sipple's Syndrome)GEORGE SAROSI, M.D., RICHARD P. DOE, M.D., PH.D.Thyroid and adrenal relationshipsPheochromocytoma and medullary carcinoma of thyroidPheochromocytomaMedullary thyroid carcinoma, parathyroid adenoma, and bilateral pheochromocytomaSolid carcinoma of the thyroid gland.Analysis of 53 casesMediastinal PheochromocytomaFamilial Amyloid-producing Medullary Thyroid Carcinoma and Pheochromocytoma A Distinct Genetic EntityR. NEIL SCHIMKE, M.D., WILLIAM H. HARTMANN, M.D.Bilateral Adrenal Pheochromocytoma and Medullary Thyroid Carcinoma 1 June 1964Volume 60, Issue 6Page: 1028-1040KeywordsGoutMedical servicesMedullary thyroid carcinomaPapillary carcinomaParathyroidParathyroid tumorsPheochromocytomaThyroidThyroid carcinomaThyroidectomy ePublished: 1 December 2008 Issue Published: 1 June 1964 PDF downloadLoading ...
No takes yet. Share an insight, caveat, or question.
David S. Nourok (1964) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: