Key result
Apolipoprotein A-I levels were inversely associated with insulin resistance and independently correlated with the presence of impaired glucose tolerance (OR 0.310).
Cross-Sectional (n=192)
No
Odds Ratio: 0.31 (95% CI 0.133–0.725)
p-value: p=0.007
Low apoA-I levels are independently associated with higher insulin resistance in patients with impaired glucose tolerance, suggesting a potential role for apoA-I in regulating glucose metabolism and insulin sensitivity.
ApoA-I may mark insulin resistance in IGT; hypothesis-generating and should not yet change practice.
BACKGROUND: Low apolipoprotein A-I (apoA-I) is an independent risk factor for atherosclerotic cardiovascular diseases. Insulin resistance predicts the progression of abnormal glucose metabolism, which is the main cause of atherosclerotic cardiovascular disease. In this study, we assessed the potential association between apoA-I levels and insulin resistance in patients with impaired glucose tolerance (IGT) and the possible link between apoA-I and IGT. METHODS: This study evaluated a cross-sectional study of 108 participants with impaired glucose tolerance (IGT group) and 84 controls (control group). ApoA-I and clinical characteristics were measured, and a homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. RESULTS: The IGT group exhibited significantly lower apoA-I and higher HOMA-IR levels than the control group (apoA-I: 1.37 ± 0.36 vs 1.57 ± 0.39 g/L; HOMA-IR: 4.21 ± 1.56 vs 2.15 ± 0.99; P < 0.001 for both). ApoA-I was negatively correlated with HOMA-IR in both the IGT and control groups (IGT group: r = -0.269, P = 0.005; control group: r = -0.262, P = 0.016). Multiple stepwise regression analysis showed that low apoA-I levels (β = -1.470, P = 0.002) were independently correlated with high HOMA-IR levels in the IGT group. Moreover, logistic regression analysis identified that low apoA-I was an independent influencing factor for IGT (β = -1.170, OR = 0.310, P = 0.007). CONCLUSIONS: ApoA-I is inversely associated with insulin resistance in patients with impaired glucose tolerance, and low apoA-I is an independent risk factor for impaired glucose tolerance. These results indicate that apoA-I plays an important role in regulating insulin sensitivity and glucose metabolism in patients with IGT.
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Feng et al. (2017) conducted a cross-sectional in Impaired glucose tolerance (n=192). Apolipoprotein A-I (apoA-I) levels vs. Normal glucose tolerance (controls) was evaluated on Impaired glucose tolerance (IGT) (OR 0.310, 95% CI 0.133-0.725, p=0.007). Apolipoprotein A-I levels were inversely associated with insulin resistance and independently correlated with the presence of impaired glucose tolerance (OR 0.310).
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