Key result
Electrical-field stimulation of rabbit isolated aorta showed that 3H-adrenaline overflow increased with time and was higher than 3H-noradrenaline at 30 Hz, though fractional profiles were similar.
Electrical-field stimulation of rabbit isolated aorta shows similar fractional profiles of 3H-adrenaline and 3H-noradrenaline release at lower frequencies, but higher 3H-adrenaline release at 30 Hz.
Warrants caution against clinical extrapolation from rabbit aorta data; leaves open whether similar release patterns exist in human sympathetic nerves.
The aim of the present work was to study the release of 3H-adrenaline (3H-A) from rabbit isolated aorta. This release was compared with that of 3H-noradrenaline (3H-NA). The stimulation-evoked 3H-overflow from aorta preloaded with 3H-A decreased with repeated stimulation (S1-S3). In contrast, prestimulation enhanced subsequent stimulation-evoked 3H-overflows. For both 3H-amines, the 3H-overflow increased concomitantly to the same degree with the number of pulses (30-1000) at 3 Hz. The time course of 3H-overflows with either 3H-A or 3H-NA was compared. In the case of 3H-A, the 3H-overflow increased with time, while for 3H-NA the 3H-overflow remained unchanged both at 3 and 10 Hz. The stimulation-evoked 3H-overflow from rings preloaded with either 3H-amine was the same at frequencies from 1 to 10 Hz, whereas at 30 Hz the 3H-overflow derived from 3H-A was higher than that using 3H-NA. An analysis of the quantitative aspects of individual stimulation-evoked 3H-overflows showed that the fractional profile did not differ using either amine. In both cases, at least 96% of the 3H-overflow evoked by stimulation at 3 or 10 Hz was contained in the initial four 2-min. fractions. The ratio between stimulation-evoked 3H-overflow and spontaneous 3H-outflow was the same for both amines at 3 Hz, while the ratio was higher for 3H-NA at 10 Hz. Rauwolscine (10(-6) M) enhanced the 3H-overflow 6-fold, while (-)-propranolol (10(-7) M) had no effect at 3 Hz.(ABSTRACT TRUNCATED AT 250 WORDS)
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Abrahamsen et al. (1986) studied this question. Electrical-field stimulation vs. 3H-noradrenaline was evaluated on 3H-overflow. Electrical-field stimulation of rabbit isolated aorta showed that 3H-adrenaline overflow increased with time and was higher than 3H-noradrenaline at 30 Hz, though fractional profiles were similar.
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