Key result
Self-reported moderate regular physical activity in postmenopausal women was associated with a significantly higher mean maximal myocardial flow reserve compared to no exercise (3.68 vs. 2.29, p=0.04).
Why the study?
Does regular physical activity improve myocardial flow reserve in postmenopausal women at risk for cardiovascular disease?
Observational (n=16)
Does regular physical activity improve myocardial flow reserve in postmenopausal women at risk for cardiovascular disease?
Absolute Event Rate: 3.68% vs 2.29%
p-value: p=0.04
Self-reported regular moderate physical activity is associated with improved myocardial flow reserve in postmenopausal women, providing a mechanistic link for the cardiovascular benefits of exercise.
BACKGROUND: Regular exercise protects against coronary heart disease (CHD) events and improves vascular reactivity. Exercise effects on myocardial flow reserve (MFR) are not well studied. METHODS: We performed dynamic N-13 ammonia positron emission tomography (PET) in 16 postmenopausal women (60 +/- 6 years) to measure myocardial blood flow (MBF) and MFR. We also obtained information from each woman on her self-reported physical activity. RESULTS: Of the 16 patients, 6 reported moderate regular physical activity, and 10 did not. Women who reported regular, at least moderate physical activity had a higher percentage increase in adenosine MBF from rest compared with women who did not exercise (268% vs. 129%, p = 0.04) and had a significantly higher mean maximal MFR (3.68 vs. 2.29, p = 0.04). CONCLUSIONS: These findings provide further mechanistic support for the beneficial cardiovascular effects of exercise.
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Duvernoy et al. (2006) conducted an observational in Postmenopausal women at risk for cardiovascular disease (n=16). Moderate regular physical activity vs. No regular physical activity was evaluated on Mean maximal myocardial flow reserve (MFR) (p=0.04). Self-reported moderate regular physical activity in postmenopausal women was associated with a significantly higher mean maximal myocardial flow reserve compared to no exercise (3.68 vs. 2.29, p=0.04).
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