Angioneurotic Edema and Rash Due to Aureomycin

Significant toxic reactions to orally administered aureomycin are believed to be rare,1and the likelihood of their frequent occurrence has been minimized in the literature. We propose in this report to call attention to a recently observed severe reaction and to review briefly the less well known side-effects which may become more common as the use of this antibiotic is extended. REPORT OF CASE C. R., a white man aged 35, had always been in good health. He had no personal or family history of allergy, and prior to the manifestations noted herein had not reacted adversely to drugs. In December 1946 he had mild subacute left maxillary sinusitis, which was treated with a penicillin nasal spray with apparent cure. Thereafter he was well until April 1948, when the left antrum was found to be chronically infected. After unsuccessful conservative treatment by an otolaryngologist a maxillary antrotomy was performed