Hypoalimentation during Hyperalimentation

The dependence of red-cell ATP concentration on plasma inorganic phosphate observed by Guest and Rapoport 35 years ago1 has since been "rediscovered"2 and confirmed repeatedly.3 The relation of red-cell ATP to extracellular phosphate is explained, in part, by the dependence of intraerythrocytic inorganic phosphate concentration on passive diffusion of phosphate from plasma, and the role of intracellular inorganic phosphate as one of several important determinants of glycolytic rate, glycolysis being the sole means of net ATP synthesis by the red cell. In addition, a considerable proportion of red-cell glyceraldehyde-3-phosphate dehydrogenase activity is membrane-bound and appears to derive one of its . . .