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The activity of serum dopamine-beta-hydroxylase does not depend solely on the presence of exogenous inhibitors: its activity also depends on the rate of release into plasma and is influenced by sympathetic activity or pathological conditions. This fluctuation may disguise the effect of an exogenous inhibitor on the enzyme. It has been shown in the present work that boiling of serum obtained from sodium diethyldithiocarbamate treated rats did not eliminate the dopamine-beta-hydroxylase inhibitory effect on a bovine adrenal dopamine-beta-hydroxylase preparation. Thus it is possible to measure the dopamine-beta-hydroxylase inhibitory effect of an exogenous inhibitor of this type without interference from the enzyme present in serum. Serum taken from rats treated with sodium diethyldithiocarbamate depressed in a time and dose dependent way the activity of bovine adrenal dopamine-beta-hydroxylase preparation.
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Jarvis et al. (1981) studied this question.
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