Key result
Injection of contrast media in dogs caused changes in circulating blood volume primarily driven by osmolality, a response that appears to be moderated by atropine.
May warrant osmolality consideration with contrast in volume-sensitive patients; leaves open human translation and atropine effects.
Changes in the circulating blood volume following injection of different contrast media and at different sites have been measured in the dog. The results confirm that osmoreceptors in the right atrium play a role for changes in blood volume following injection of a contrast medium. The differential response to individual agents was mainly a function of their osmolality. Atropine appears to moderate the changes.
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Barbé et al. (1980) studied this question. Contrast media vs. Different contrast media was evaluated on Changes in circulating blood volume. Injection of contrast media in dogs caused changes in circulating blood volume primarily driven by osmolality, a response that appears to be moderated by atropine.
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