Until recently, the existence of a Na+-K+-2Cl− cotransporter (NKCC) in skeletal muscle was unclear. Recent evidence shows that the NKCC is strongly expressed and provides both K+ and water transport functions in resting and contracting skeletal muscle. The contribution of NKCC activity to K+ and volume regulation in skeletal muscle has potential consequences for muscle contractility and metabolism.
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Gosmanov et al. (2003) studied this question.
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