Breakdown products of fibrin and fibrinogen: molecular mechanisms and clinical implications

a number of common features. Fig. The conservation of both the NH2-terminal amino-acids1617 of the Ao-chains suggests that the initial lysis of the Aa-chain takes place at their carboxy ends. Peptides of about 40 000 molecular weight are released rather rapidly, leaving the NH2-terminal remnant of the Ao-chain disulphide bonded to intact BP and y chains. The next reaction involves the removal of peptides 10 copyright.