Diagnostic evaluation uncovers falsely decreased point-of-care creatinine results in oncology patients, suggesting cartridge lot-to-lot variation beyond chemotherapy interference.
The goals of this study were to assess the use of the I-STAT for blood creatinine measurement in oncology patients and to determine whether chemotherapy or other factors contributed to the discrepant point-of-care creatinine test results observed in specimens from patients in ambulatory oncology settings. Our studies led us to consider other possible causes of observed discrepancies beyond the effects of chemotherapeutic drugs, including lot-to-lot variation in I-STAT reagent cartridges.
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Bahar et al. (2016) studied this question.
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