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A prospective program for the prenatal detection of neural tube defects in a high-risk pregnancy group has been under way for one year. Twenty high-risk mothers have undergone a complete prenatal work-up, including sonography, amniocentesis, and amniotic fluid and maternal serum α-fetoprotein quantitation. Within this group, two cases were prospectively diagnosed and were later confirmed. (JAMA236:1251-1254, 1976)
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J. N. Macri (1976) studied this question.
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