On Coagulation and Fibrinolysis in Conservatively Treated Chronic Uraemia

Factors of the coagulation and fibrinolytic systems have been studied in 50 conservatively treated patients with chronic uraemia of varying origin and serum creatinine levels of 2.1–27.5 mg/100 ml. The patients were grouped according to serum creatinine level, aetiology of renal failure and actual treatment. The investigation showed that decreased platelet adhesiveness, prolonged Ivy bleeding time and bleeding tendency, increased content of certain coagulation factors (factor VIII, P & P, fibrinogen), decreased fibrinolytic activity and increased content of inhibitors of plasminogen activation were common. The platelet adhesiveness decreased, the bleeding time and the bleeding tendency increased with increasing serum creatinine. Factor VIII, P & P and fibrinogen tended first to rise and then to fall, while the fibrinolytic activity and the content of inhibitors of plasminogen activation did not vary with renal function. No certain correlation was found between the changes observed and the aetiology of uraemia or actual treatment.