Key result
In a Chinese Han population, the ZSCAN25 rs10242455 polymorphism was associated with reduced ischemic stroke susceptibility (OR 0.56), while CYP2E1 rs2070672 and rs2515641 increased stroke risk.
Why the study?
The study aimed to explore the relationship between ZSCAN25 and CYP2E1 polymorphisms and ischemic stroke susceptibility among a Chinese Han population.
Do ZSCAN25 and CYP2E1 polymorphisms affect the risk of ischemic stroke in a Chinese Han population?
Case-Control (n=957)
Double-blind
No
Do ZSCAN25 and CYP2E1 polymorphisms affect the risk of ischemic stroke in a Chinese Han population?
Odds Ratio: 0.56 (95% CI 0.34–0.93)
p-value: p=0.024
In a Chinese Han population, the ZSCAN25 rs10242455 polymorphism is associated with a reduced risk of ischemic stroke, whereas CYP2E1 rs2070672 and rs2515641 polymorphisms are associated with an increased risk.
Should not yet change practice; hypothesis-generating for genetic IS risk in Chinese Han, needing replication.
Background: We aimed to explore the relationship between ZSCAN25 and CYP2E1 polymorphisms and Ischemic stroke (IS) susceptibility among a Chinese Han population.Methods: We enrolled 477 patients with IS and 480 age- and sex- matched health controls. Genotyping of the ZSCAN25 rs10242455, CYP2E1 rs2070672 and rs2515641 were performed by Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression analysis.Results: Rs10242455 (OR = 0.56, 95% CI: 0.34–0.93, p = 0.024) was associated with a reduced IS susceptibility, while rs2070672 (OR = 1.40, 95% CI: 1.12–1.75, p = 0.003) and rs2515641 (OR = 1.29, 95% CI: 1.01–1.64, p = 0.041) with an increased IS occurrence. Rs2070672 was observed to correlate with IS risk (OR = 4.06, p = 0.038) at age > 64 years, and rs10242455 (OR = 0.45, p = 0.021) and rs2070672 (OR = 3.28, p = 0.024) affected IS risk in males. In addition, rs10242455 (OR = 1.72, p = 0.014) was significantly associated with hypertension in IS patients.Conclusion: Our study firstly found that rs10242455 in ZSCAN25, rs2070672 and rs2515641 in CYP2E1 were associated with the occurrence of IS in a Chinese Han population.
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Yuan et al. (2020) conducted a case-control in Ischemic stroke (n=957). ZSCAN25 rs10242455 polymorphism vs. Wild-type genotype (AA) was evaluated on Ischemic stroke susceptibility (GG vs AA genotype) (OR 0.56, 95% CI 0.34-0.93, p=0.024). In a Chinese Han population, the ZSCAN25 rs10242455 polymorphism was associated with reduced ischemic stroke susceptibility (OR 0.56), while CYP2E1 rs2070672 and rs2515641 increased stroke risk.
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