Key result
Primary percutaneous coronary intervention did not significantly improve left ventricular ejection fraction at one-year follow-up in patients with acute myocardial infarction (mean increase of 0.47%, p=0.2524).
Why the study?
Primary PCI is the gold standard for STEMI, but its impact on left ventricular function recovery in acute MI patients required assessment.
Does primary percutaneous coronary intervention (PCI) improve left ventricular ejection fraction (LVEF) recovery in patients with acute myocardial infarction?
Cohort (n=300)
No
Does primary percutaneous coronary intervention (PCI) improve left ventricular ejection fraction (LVEF) recovery in patients with acute myocardial infarction?
Primary PCI alone did not significantly improve LVEF at one year in AMI patients, highlighting the need for adjunctive therapies to address high rates of microvascular obstruction and MACE.
May support primary PCI for LV recovery post-MI; leaves open need for prospective confirmation.
Objective: Primary percutaneous coronary intervention (PCI) has emerged as the gold standard for the management of ST-segment elevation myocardial infarction (STEMI), significantly improving patient outcomes. The objective of this study was to assess the impact of primary PCI on left ventricular function recovery in Acute MI patients. Methodology: A retrospective study was conducted at the Department of Cardiology, Hayatabad Medical Complex, Peshawar, from July 2017 to June 2018. A total of 300 patients (mean age: 61.1 ± 13.32 years; 60% male, 40% female) were included. Pre-PCI and post-PCI Left Ventricular Ejection Fraction (LVEF) were analyzed, along with the incidence of microvascular obstruction (MVO) and major adverse cardiovascular events (MACE). Statistical analysis was performed using paired t-tests and chi-square tests, with significance set at p<0.05. Results: The mean pre-PCI LVEF was 48.47% (± 7.99), increasing to 49.14% (± 8.51) at follow-up (p = 0.2524). MVO was present in 56.33% of patients, while 49% experienced MACE. Gender differences in MACE incidence (male: 52%, female: 46%) were not statistically significant (p >0.05). Conclusion: PCI alone did not significantly improve LVEF, indicating the need for additional therapeutic strategies. High rates of MVO and MACE highlight the necessity for comprehensive post-PCI management to enhance cardiac recovery.
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Khan et al. (2025) conducted a cohort in Acute Myocardial Infarction (n=300). Primary percutaneous coronary intervention vs. Pre-PCI baseline was evaluated on Left Ventricular Ejection Fraction (LVEF) recovery (MD 0.47%, p=0.2524). Primary percutaneous coronary intervention did not significantly improve left ventricular ejection fraction at one-year follow-up in patients with acute myocardial infarction (mean increase of 0.47%, p=0.2524).
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