Key result
Biomarkers detected by gene technology and proteomics techniques have revolutionized the diagnosis and management of organ damage in the field of cardiovascular surgery.
Innovative technologies in gene technology and proteomics have enabled the discovery and clinical use of biomarkers for early diagnosis of organ damage after cardiac surgery.
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May support biomarker use for post-cardiac surgery organ damage detection; leaves open need for prospective validation before practice change.
A biomarker is a measureable substance produced by the body and used to diagnose or determine the biologic state. Most biomarkers used in the clinical medicine are the genes, proteins or other chemical substances that are expressed in the pathology or organ damage, allowing for early and fast diagnosis and treatment. Ideally, biomarkers must be generally highly sensitive in order to make an early diagnosis; provide certain cut-off values to enable risk assessment, therapeutic guidance and have prognostic value. Cardiopulmonary bypass (CPB) is a model of extracorporeal circulation consisting primarily of a pump, a reservoir and an oxygenerator. At the initiation of CPB, blood is drained from the patient into the extracorporeal circuit which has non-endothelial surface. The inflammatory process occurs after cardiac surgery in varied degrees depending on the genotypes and peroperative parameters or complexity of the cardiac pathology. This process is mediated by cellular, noncellular or humoral components of the blood. Today, safe clinical biomarkers are detected by gene technology and proteomics techniques. Using these innovative technologies, the discovery, validation and clinical use of several biomarkers have revolutionized the diagnosis and management in the field of cardiovascular surgery as well as other major medical disciplines.
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Tijen Alkan Bozkaya (2015) conducted a review in Organ damage after cardiac surgery. Biomarkers was evaluated. Biomarkers detected by gene technology and proteomics techniques have revolutionized the diagnosis and management of organ damage in the field of cardiovascular surgery.
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