Key result
Corrected QT variability from peak to recovery correlated with coronary artery disease (p=0.03), though ROC analysis showed no significant diagnostic accuracy for predicting CAD presence or severity.
Why the study?
While the relationship between QT prolongation and myocardial ischemia is well known, few studies have correlated corrected QT interval and heart rate recovery with the severity of coronary artery disease.
Do heart rate and QT parameters during stress exercise testing predict the presence and severity of stable coronary artery disease?
Observational (n=251)
No
Do heart rate and QT parameters during stress exercise testing predict the presence and severity of stable coronary artery disease?
Although corrected QT variability correlates with coronary artery disease, simple heart rate and QT parameters during stress testing lack significant diagnostic accuracy for predicting CAD presence or severity.
Answers are grounded in this paper and cite their sources.
Should not yet inform CAD diagnosis via stress testing; leaves open QT variability's role in future risk-stratification studies.
Aim: The relationship between QT prolongation and myocardial ischemia is well known, however not many studies have correlated corrected QT interval and heart rate recovery with the severity of coronary artery disease (CAD). Methods: This was a single-center, prospective, observational study which included 127 patients with CAD and 124 patients without CAD. Results: Corrected QT variability from peak to recovery correlated well with CAD with a p value of 0.03. Receiver operative characteristic analysis did not show any significant diagnostic accuracy with any heart rate or QT parameters for predicting the presence or severity of CAD. Conclusion: Coronary artery disease is predicted by reduced ability of the heart rate to rise from rest to peak exercise and reduced recovery of heart rate and corrected QT from peak exercise to recovery at 1 min.
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Rajarajan et al. (2021) conducted an observational in Coronary artery disease (n=251). Corrected QT interval and heart rate recovery was evaluated on Presence or severity of coronary artery disease (p=0.03). Corrected QT variability from peak to recovery correlated with coronary artery disease (p=0.03), though ROC analysis showed no significant diagnostic accuracy for predicting CAD presence or severity.
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