Key result
Elevated circulating MMP-9 serum levels were independently associated with an increased risk of new embolic events during infective endocarditis (adjusted OR 3.5 per 1-SD increase).
Why the study?
Does circulating MMP-9 predict embolic events in patients with infective endocarditis?
Observational (n=84)
No
Does circulating MMP-9 predict embolic events in patients with infective endocarditis?
Odds Ratio: 3.5 (95% CI 1.19–10.34)
p-value: p=0.02
Elevated MMP-9 serum levels at admission independently predict the risk of embolic events during antibiotic therapy for infective endocarditis, providing incremental prognostic value over vegetation length.
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MMP-9 may refine embolic risk stratification in endocarditis; hypothesis-generating and should not change practice without validation.
Thuny et al. (2011) conducted an observational in Infective endocarditis (n=84). Elevated MMP-9 serum level vs. Lower MMP-9 serum level was evaluated on New embolic events (new-EE) during antibiotic therapy (OR 3.5, 95% CI 1.19-10.34, p=0.02). Elevated circulating MMP-9 serum levels were independently associated with an increased risk of new embolic events during infective endocarditis (adjusted OR 3.5 per 1-SD increase).
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