Key result
Vagus nerve stimulation significantly decreased pro-inflammatory cytokines TNF-α and IL-1β (P < 0.01) and increased anti-inflammatory IL-10 in rabbits with explosive brain injury.
Why the study?
Does vagus nerve stimulation reduce brain edema and alter inflammatory cytokines in rabbits with brain explosive injury?
Does vagus nerve stimulation reduce brain edema and alter inflammatory cytokines in rabbits with brain explosive injury?
Vagus nerve stimulation may exert neuroprotective effects against explosive brain injury by regulating inflammatory cytokines.
Does not support clinical use; leaves open translation of anti-inflammatory effects from this rabbit model.
Previous studies have shown that vagus nerve stimulation can improve the prognosis of traumatic brain injury. The aim of this study was to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in rabbits with brain explosive injury. Rabbits with brain explosive injury received continuous stimulation (10 V, 5 Hz, 5 ms, 20 minutes) of the right cervical vagus nerve. Tumor necrosis factor-α, interleukin-1β and interleukin-10 concentrations were detected in serum and brain tissues, and water content in brain tissues was measured. Results showed that vagus nerve stimulation could reduce the degree of brain edema, decrease tumor necrosis factor-α and interleukin-1β concentrations, and increase interleukin-10 concentration after brain explosive injury in rabbits. These data suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-α, interleukin-1β and interleukin-10 in the serum and brain tissue.
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Yu et al. (2014) studied Traumatic brain injury (explosive injury) (n=28). Vagus nerve stimulation vs. Explosive injury without stimulation was evaluated on Pro-inflammatory cytokines (TNF-α, IL-1β) and anti-inflammatory cytokine (IL-10) levels (p=<0.01). Vagus nerve stimulation significantly decreased pro-inflammatory cytokines TNF-α and IL-1β (P < 0.01) and increased anti-inflammatory IL-10 in rabbits with explosive brain injury.
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