Various anomalies were induced in Drosophila melanogaster by dietary administration of 5‐bromodeoxyuridine (5‐BUdR). Contraction of the proboscis was the most conspicuous effect. Others included wings that resembled those of a vestigial wing mutant, twisted and/or deformed (occasionally fused) rear legs, and twin spots on the posterior half of the pterothorax. In view of many studies that have demonstrated that 5‐BUdR incorporation into DNA is the main determinant of the biological activity of this compound, the altered patterns of differentiation produced by this treatment suggest interference with certain metabolic pathways. Teratogenic effects induced by 5‐BUdR in other systems and possible causes for the observed defects are discussed.
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Gilbert et al. (1973) studied this question.
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