Halothane related liver affection in an anaesthetist.

Halothane has been used as an anaesthetic since the late 1950s; it is normally administered together with laughing gas (N20) and oxygen, the halothane content of the mixture being around 0-5-2-0% (5000-20 000 ppm). There is strong evidence that halothane is hepatotoxic both in patients who have undergone surgery and animals used for experimental purposes.13 Repeated exposure at irregular intervals has caused serious liver dysfunction in guinea pigs.4 An attempt has been made to determine the extent to which