Unsaturated monohydroxy bile acids in cholestatic liver disease

In a study of the different bile acid classes in the serum of patients with cholestatic liver disease it was found that 12 out of 15 patients had conjugated monohydroxy bile acids in amounts up to 35% of serum total bile acids (Murphy et al., 1972). These compounds, which were detected after t.l.c. on silica gel (Gregg, 1966), had RF values corresponding to