Key result
Cardiac valve calcification was independently associated with a significantly increased risk of 1-year all-cause mortality (HR 3.427) in diabetic patients following lower-extremity amputation.
Why the study?
Cardiac valve calcification predisposes patients to a higher risk of adverse events, but its association with 1-year mortality in diabetic patients after lower-extremity amputation was unknown.
Does cardiac valve calcification predict 1-year mortality in diabetic patients after lower-extremity amputation?
Cohort (n=93)
No
Does cardiac valve calcification predict 1-year mortality in diabetic patients after lower-extremity amputation?
Cardiac valve calcification is an independent predictor of 1-year all-cause mortality in diabetic patients following lower-extremity amputation, and its combination with the Revised Cardiac Risk Index improves prognostic accuracy.
Answers are grounded in this paper and cite their sources.
Cardiac valve calcification may flag higher 1-year mortality risk after diabetic amputation; leaves open whether screening or intervention improves outcomes.
Background: Cardiac valve calcification predisposes patients to a higher risk of adverse events. This study aimed to investigate the association between cardiac valve calcification and 1-year mortality in diabetic patients after lower-extremity amputation. Methods: Diabetic patients requiring lower-extremity amputation were retrospectively studied. Preoperative detailed anamnesis was taken. Cardiac valve calcification was assessed using echocardiography at baseline. One-year follow-up was conducted and included clinical visits, hospital record assessment, and telephone reviews to obtain the survival status of patients. Results: Ninety-three diabetic patients participated in the study. The 1-year follow-up mortality rate after amputation was 24.7%. Compared to the survival group, the prevalence of cardiac valve calcification and RCRI were higher in the mortality group. In the Cox regression analysis, cardiac valvular calcification (HR=3.427, 95% CI=1.125-10.443, P=0.030) was found to be an independent predictor of all-cause mortality after amputation. In addition, the patients with both aortic valve calcification and mitral annular calcification had a higher all-cause mortality rate (50%). Receiver operator characteristic curve analysis showed a stronger predictive ability when using a combination of calcified valve number and RCRI (AUC=0.786 95%, CI=0.676-0.896, P=0.000). Conclusion: In diabetic patients after lower-extremity amputation, cardiac valve calcification was associated with all-cause mortality during 1-year follow-up. Combination of calcified valves number and RCRI showed a stronger predictive valuefor mortality.
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Ye et al. (2022) conducted a cohort in Diabetic foot ulcers requiring lower-extremity amputation (n=93). Cardiac valve calcification vs. No cardiac valve calcification was evaluated on 1-year all-cause mortality (HR 3.427, 95% CI 1.125-10.443, p=0.030). Cardiac valve calcification was independently associated with a significantly increased risk of 1-year all-cause mortality (HR 3.427) in diabetic patients following lower-extremity amputation.
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