Key result
After 4-17 weeks, partial excision and mincing of pigeon metapatagialis muscles resulted in regeneration of fast fibers similar to controls, whereas slow fibers were much less regenerated.
Population
Pigeon metapatagialis muscles containing fast fibers in two slips and slow fibers in another slip
Comparison
Partial excision, mincing, and replacement into… vs Control muscles
Design
Preclinical
Follow-up
4-17 weeks
Authors
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Differential fast versus slow fiber regeneration after injury in pigeons; hypothesis-generating for mechanisms and leaves open mammalian translation.
In a pigeon model, fast muscle fibers regenerate more completely than slow muscle fibers after excision and mincing, possibly due to the complex multiple innervation pattern of slow fibers.
Hikida et al. (1974) studied Muscle regeneration. Partial excision and mincing vs. Controls was evaluated on Pattern of fiber types, ATPase and oxidative enzymes, and ultrastructural changes. After 4-17 weeks, partial excision and mincing of pigeon metapatagialis muscles resulted in regeneration of fast fibers similar to controls, whereas slow fibers were much less regenerated.
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