Key result
Intranasal dexmedetomidine at 3μg/kg significantly improved sedation, separation anxiety, emergence delirium, and face mask acceptance scores compared to 2μg/kg (P<0.05).
Why the study?
Emergence agitation can persist for up to two days postoperatively, prompting a comparison of 2μg/kg versus 3μg/kg intranasal dexmedetomidine for its prevention in children undergoing adenotonsillectomy.
Does intranasal dexmedetomidine 3μg/kg reduce emergence agitation compared to 2μg/kg in children undergoing adenotonsillectomy under sevoflurane anesthesia?
RCT (n=40)
Double-blind
parallel
Does intranasal dexmedetomidine 3μg/kg reduce emergence agitation compared to 2μg/kg in children undergoing adenotonsillectomy under sevoflurane anesthesia?
p-value: p=<0.05
A higher dose of intranasal dexmedetomidine (3μg/kg) is more effective than 2μg/kg in reducing emergence agitation and improving sedation scores in children undergoing adenotonsillectomy.
Intranasal DEX dosing for pediatric EA remains inconclusive; leaves open optimal regimen before practice change.
Emergence agitation (EA) is an aberrant mental condition arises during the transformation fromunconsciousness to full awareness and can persist for up to two days in the early postoperative period.This study compared 2μg/kg versus 3μg/kg intranasal dexmedetomidine (DEX) in reducingEA in children undergoing adenotonsillectomy.This randomized parallel double-blinded research involved 40 pediatric patients aged 2-10 yearsold of both sexes were classified by American Society of Anesthesiologists physical status of I, &II undergoing adenotonsillectomy with sevoflurane anesthesia. They were allocated into two groups,GI: received intranasal DEX (2μg/kg), and GII: received intranasal DEX (3μg/kg). General anesthesiawas done by face mask with sevoflurane 6-8% inhalation and maintenance at 2-4%.The results showed that GII had a significantly better Ramsay sedation score, parental separationanxiety scale, Watcha scale emergence delirium, and face mask acceptance scores compared toGI (P<0.05). GII had a significantly lower flacc score compared to GI (P =0.017), but without significantdifference between both as to parents' satisfaction scores
No takes yet. Share an insight, caveat, or question.
WAEL HUSSEIN (2023) conducted an RCT in Emergence agitation (n=40). Intranasal dexmedetomidine vs. Intranasal dexmedetomidine 2μg/kg was evaluated on Ramsay sedation score, parental separation anxiety scale, Watcha scale emergence delirium, and face mask acceptance scores (p=<0.05). Intranasal dexmedetomidine at 3μg/kg significantly improved sedation, separation anxiety, emergence delirium, and face mask acceptance scores compared to 2μg/kg (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: