Following single intravenous injections of succinylcholine chloride in doses of 0.5 to 4.0 mg./kg., the duration of muscle paralysis to 50 per cent recovery lasted from 5.9 to 17.1 minutes; duration was dose dependent. Following intramuscular injection of succinylcholine chloride, 1.0 to 4.0 mg./kg., the latent period was between 1.8 and 2.7 minutes, and dependent on both dose and the addition of hyaluronidase. The duration of weakness was quite variable, with 50 per cent recovery requiring between 20 and 27 minutes. There was a strong suggestion that the formation of Phase II nondepolarizing block is not only dependent on the dose of succinylcholine chloride, but upon the duration of depolarization of the myoneural junction.
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Walts et al. (1967) studied this question.