Key result
Pathologic studies of two fatal cases with similar clinical features during the 1998 hand, foot, and mouth disease outbreak in Taiwan revealed two different causative agents (enterovirus 71 and Japanese encephalitis virus).
Case Report (n=2)
Postmortem examinations and modern pathologic techniques are crucial in outbreak investigations to identify different causative agents in cases with similar clinical features.
Postmortem studies may distinguish EV71 from JEV in fatal HFMD-like illness; case reports leave open broader diagnostic implications for current outbreaks.
In 1998, an outbreak of enterovirus 71-associated hand, foot, and mouth disease occurred in Taiwan. Pathologic studies of two fatal cases with similar clinical features revealed two different causative agents, emphasizing the need for postmortem examinations and modern pathologic techniques in an outbreak investigation.
No takes yet. Share an insight, caveat, or question.
Shieh et al. (2001) conducted a case report in Fatal hand, foot, and mouth disease / encephalomyelitis (n=2). Pathologic examination (IHC, in situ hybridization, electron microscopy) was evaluated on Identification of causative agent. Pathologic studies of two fatal cases with similar clinical features during the 1998 hand, foot, and mouth disease outbreak in Taiwan revealed two different causative agents (enterovirus 71 and Japanese encephalitis virus).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: