Key result
Flow cytometry analysis of a 25-year-old male with multiple recurrent familial cardiac myxomas revealed an aneuploid DNA content.
Case Report (n=1)
No
Recurrent familial cardiac myxomas may be associated with aneuploid DNA content, highlighting the need for genetic profiling and long-term echocardiographic follow-up in young patients and their first-degree relatives.
May warrant genetic evaluation in familial myxoma kindreds; leaves open whether aneuploidy predicts recurrence or guides surveillance.
We present a 25 year old Caucasian male patient with multiple recurrences of cardiac myxomas after surgical removal of the original tumor. His mother was operated on for right ventricular myxoma. The genetic analyses disclosed an aneuploid DNA content by flow cytometry analysis. The familial form of the cardiac myxomas must be distinguished from Carney complex syndrome. A long- term echocardiographic follow up is recommended to patients and their first degree relatives with cardiac myxomas.
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Kontogiorgi et al. (2013) conducted a case report in Recurrent cardiac myxoma (n=1). Surgical resection and DNA flow cytometry was evaluated on DNA ploidy status and tumor recurrence. Flow cytometry analysis of a 25-year-old male with multiple recurrent familial cardiac myxomas revealed an aneuploid DNA content.
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