Key result
A single depot injection of betamethasone acetate/phosphate resulted in zero complications or signs of adrenocortical insufficiency across 1461 steroid-treated surgical cases.
Why the study?
Does a single injection of betamethasone acetate/phosphate prevent adrenocortical insufficiency in steroid-treated surgical patients?
Does a single injection of betamethasone acetate/phosphate prevent adrenocortical insufficiency in steroid-treated surgical patients?
A single depot injection of betamethasone acetate/phosphate appears safe and effective for glucocorticoid substitution in steroid-treated surgical patients.
Answers are grounded in this paper and cite their sources.
Supports safety of single depot betamethasone in steroid-treated surgery; hypothesis-generating and requires randomized trials before practice change.
A rational approach to glucocorticoid substitution therapy in steroid-treated surgical patients is described. Betamethasone acetate/phosphate as a single injection, depot-preparation, has been used in 1461 steroid-treated cases of major and minor surgery. No complications or signs of adrenocortical insufficiency druing the pre- and post-operative period were noted.
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Gran et al. (1978) studied this question. A single depot injection of betamethasone acetate/phosphate resulted in zero complications or signs of adrenocortical insufficiency across 1461 steroid-treated surgical cases.
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