Distribution of Cadmium 109 and Zinc 65 in Mice of Inbred Strains

Distribution of subcutaneously injected cadmium 109 (109Cd) and zinc 65 (65Zn) was studied in mature male mice of four different inbred strains. Mice of CBA/J and DBA/1J strains, which are known to be susceptible to cadmium-induced testicular necrobiosis, exhibited a greater uptake of 109Cd by the testes than cadmium-resistant strains C57BL/6J and BALB/cJ. The ratio of 109Cd/65Zn in the testes of cadmium-sensitive strains was several times higher than in the testes of cadmium-resistant strains. In all animals, the liver and the kidney tissue concentrated more cadmium than zinc. In other tissues, the uptake of zinc predominated that of cadmium.