Cytomegalovirus Colitis Presenting as a Rectal Mass

Cytomegalovirus (CMV) is a common cause of colitis, particularly in immunosuppressed patients. Rarely, CMV can present as a mass lesion that endoscopically appears consistent with adenocarcinoma. There are no reported cases of a CMV mass lesion inducing rectal prolapse. We present a case of CMV colitis presenting as a rectal mass mimicking adenocarcinoma and causing rectal prolapse in an immunosuppressed female.