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The succinate receptor is activated by physiological levels of succinate and plays a role in regulating renin production, retinal angiogenesis, inflammation, and the immune response.
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Succinate receptor roles in inflammation and renin production highlight potential therapeutic target; leaves open clinical translation pending prospective validation.
Nomenclature as recommended by NC-IUPHAR [8]. The Succinate receptor was identified as being activated by physiological levels of the Kreb's cycle intermediate succinate and other dicarboxylic acids such as maleate in 2004. Since its pairing with its endogenous ligand, the receptor has been the focus of intensive research and its role has been evidenced in various (patho)physiological processes such as regulation of renin production, retinal angiogenesis, inflammation or the immune response.
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Davenport et al. (2021) studied this question. Succinate receptor was evaluated. The succinate receptor is activated by physiological levels of succinate and plays a role in regulating renin production, retinal angiogenesis, inflammation, and the immune response.
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