Experimental study demonstrates asymmetric Diels–Alder reactions of 3-vinylindoles via thiourea catalysis, highlighting efficient access to chiral carbazoles.
Diels or no Diels? A bifunctional organic catalyst based on the thiourea motif is able to coordinate both diene and dienophile in an unprecedented asymmetric Diels–Alder reaction of 3-vinylindole derivatives, giving a rapid access to optically active tetra- and hexahydrocarbazoles with excellent results in terms of yields, diastereoselectivities, and enantioselectivities.
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Gioia et al. (2008) studied this question.
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