Nitrogen-containing chiral heterocycles represent important structural elements with wide occurrence in natural and unnatural compounds exhibiting important biological activities. Herein, we describe our recent endeavors directed toward the Brønsted acid-catalyzed 1,3-dipolar cycloaddition and alkylation reactions, together with the metal/Brønsted acid relay catalytic cascade reactions to access some typical nitrogenous heterocyclic structures and natural alkaloids, including (+)-folicanthine and (+)-gliocladin C.
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Yu et al. (2014) studied this question.