Aluminum phosphate (AlPO4) efficiently catalyzed the condensation of 1,3-ketoesters with primary amines under free solvent conditions. The catalyst has been prepared and characterized by powder XRD and FT-IR studies. The AlPO4 synthesis was performed in water at room temperature from AlCl3 and H3PO4 in the presence of ammonia solution. Resultant material showed good catalytic efficiency in condensation of 1,3-ketoesters with primary amines using a domestic microwave oven with no solvent. The reaction was complete in 7 min to afford β-enamino esters in a high yield and high selectivity.
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Harrad et al. (2012) studied this question.
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