From Diels-Alder reactions to peptide synthesis-the spectrum of reactions catalyzed by RNA keeps on growing. These developments became possible by new methods for the selection of catalysts from combinatorial libraries by using linker-coupled reactants. The formula on the right shows the product of a Diels-Alder reaction. Biot-OH=biotin.
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Frauendorf et al. (1998) studied this question.