Asymmetrische Synthesen, VII. Herstellung optisch aktiver Aminonitrile

Asymmetric Syntheses, VII1). Synthesis of Optically Active Aminonitriles The optically active crystalline aminonitriles 3a–n and 4o are obtained from ketones 1a–o, (4S,5S)‐(+)‐5‐amino‐2,2‐dimethyl‐4‐phenyl‐l,3‐dioxane (2), and hydrocyanic acid. The absolute configuration of the newly formed centers of chirality (* in 3 and 4), and the epimer equilibria (table 1) in solution are determined by 1H NMR spectroscopy.